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Regularisation sets the length scale over which intensity non-uniformity correction may adjust intensities. With no regularisation, the length scale is short, and the correction may attempt to correct "non-uniformity" which is actually grey-white contrast. The regularisation needs to be matched to the length scale of the RF inhomogeneity in your images. In my opinion, light regularisation will work well at 3T (not tested), whereas medium is optimum for 1.5T.

To be included here: Profile plots taken from the difference image of the (bias) corrected and uncorrected images. These show the length scale of variation of the bias correction for different regularisations...

Segmented Brain Image

Last modified by Jon Jackson on Wed Dec 31 11:06:47 GMT 2008

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